Why does neuroblastoma cause Opsoclonus?

OMAS may be caused by an immune reaction to a tumor called neuroblastoma or an immune reaction to a viral illness. The immune reaction causes the body to produce antibodies to the cerebellum, which is located in the back of the brain.

What does Opsoclonus look like?

Opsoclonus may look like a a chaotic “shimmer” on direct observation. Ocular flutter is often missed by clinicians who lack the ability to view the eyes with a video system.

Can OMS be cured?

There is no known definitive cure for OMS. However, several drugs have proven to be effective in their treatment. Some of medication used to treat the symptoms are: ACTH has shown improvements in symptoms but can result in an incomplete recovery with residual deficits.

What is kinsbourne syndrome?

Kinsbourne syndrome is a rare neurological disorder that primarily affects children previously healthy and aged between 6 and 36 months. It is characterized by opsoclonus (rapid, irregular, horizontal and vertical eye movements) and myoclonus that may affect trunk, limbs or face, and cerebellar ataxia.

What is OMS and neuroblastoma?

In OMS, a small tumor in the body (called a neuroblastoma) or a viral infection triggers the immune system to attack the nervous system. The symptoms of OMS usually begin abruptly and can include rapid, repeated eye movements (opsoclonus or “dancing eyes”), jerking movements (myoclonus), and loss of balance (ataxia).

Is Wilms tumor common?

Wilms’ tumor is the most common type of kidney cancer in children. Wilms’ tumor is a rare kidney cancer that primarily affects children. Also known as nephroblastoma, it’s the most common cancer of the kidneys in children. Wilms’ tumor most often affects children ages 3 to 4 and becomes much less common after age 5.

How do you get OMS?

The onset of OMS is usually abrupt and often severe. The disease may become chronic. OMS typically occurs in association with tumors (neuroblastomas), or following a viral or bacterial infection.

Can opsoclonus be intermittent?

Intermittent opsoclonus can occur in healthy neonates, resolving by 6 months of age, sometimes with a transient stage of ocular flutter (14): neuroimaging, electrophysiologic and metabolic studies are normal.

What does OMS stand for in medical terms?

Opsoclonus-myoclonus syndrome (OMS) is an inflammatory neurological disorder, often with paraneoplastic etiology. It is characterized by associated ocular, motor, behavioral, sleep, and language disturbances. The onset is usually abrupt, often severe, and it can become chronic.

What does OMS stand for in medical school?

Oral and maxillofacial surgery. Oral Morphine Solution. Osteopathic Medical Student, a student Doctor of Osteopathic Medicine.

How do you treat an OMS?

There are no official treatment recommendations for OMS. Management may involve: Surgery, chemotherapy, and/or radiation: When there is a tumor present, treatment such as surgery for tumor removal, chemotherapy, or radiation may be required.

Is Wilms tumor fatal?

Wilms tumor is a rare kidney cancer that is highly treatable. Most kids with Wilms tumor survive and go on to live normal, healthy lives. Also known as nephroblastoma, Wilms tumor can affect both kidneys, but usually develops in just one.

What is the prognosis for neuroblastoma in opsomyoclonus?

If neuroblastoma is found in a patient with opsomyoclonus, it is generally small with relatively favorable histology and the prognosis, in terms of survival, is very good. The neurologic symptoms may be treated with corticosteroids and/or ACTH, but often persist despite the medical treatment and surgical resection 2.

What kind of tumor is associated with opsoclonus?

We want to hear from you. Opsoclonus-myoclonus syndrome is often associated with the presence of a tumor (such as neuroblastoma) and referred to as a paraneoplastic syndrome.

What is the clinical presentation of opsomyoclonus?

Opsomyoclonus (OMS), also known as dancing eyes-dancing feet syndrome and opsoclonus-myoclonus syndrome, is a clinical syndrome which has a strong association with neuroblastoma. Clinical presentation The “opso-“ refers to the presence of inter…

What is the clinical presentation of a neuroblastoma?

Clinical presentation. The “opso-“ refers to the presence of intermittent jerky eye movements (dancing eyes) and the “myoclonus” to myoclonic jerks and cerebellar ataxia (dancing feet). Although only 2% of patients with neuroblastoma present with opsomyoclonus, up to 50% of patients with opsomyoclonus are ultimately found to have a neuroblastoma 1.