What type of mutagen is colchicine?
Colchicine is an important mutagen that works by preventing the microtubules formation and doubles the number of chromosomes. It is commonly used to develop polyploid plants and functions as a mitotic poison by producing many mutagenic effects on plants [28].
How does colchicine cause polyploidy?
As microtubules function in chromosome segregation, colchicine induces polyploidy by preventing the segregation of chromosomes during meiosis that results into half of the gametes (sex cells) containing double the chromosome number than usual.
What is colchicine plant?
Colchicine is a toxic chemical that is often used to induce polyploidy in plants. Basically, the colchicine prevents the microtubule formation during cell division, thus the chromosomes do not pull apart like they normally do.
What is Amphi polyploidy?
There are mainly two types of polyploidy- autopolyploidy and allo(amphi)polyploidy. There are various types under each of these major divisions. 1. Autopolyploidy is the presence of multiple sets of chromosomes derived from a single genotype.
Is Colchicine used for gout?
About colchicine Colchicine is a medicine for treating inflammation and pain. It can be used to: treat flare-ups (attacks) of gout. prevent increased flare-ups of gout when you first start on a medicine like allopurinol – taken to manage your condition long term.
Is colchicine from a plant?
Colchicine is one of the oldest remedies still in use today. It is derived from the bulb-like corms of the Colchicum autumnale plant, also known as autumn crocus. Its history as an herbal remedy for joint pain goes back at least to the 1500 BCE Egyptian manuscript, the Ebers Papyrus (Figure 1).
What is the source of colchicine?
Colchicine. Colchicine is an alkaloid derived from two plants of the lily family, Colchicum autumnale and Gloriosa superba, that was first recommended for the treatment of gout in the sixth century A.D.7 It remains widely in use today for the treatment of acute gout.
How does colchicine work for gout?
For gout, colchicine works by reducing the inflammation caused by crystals of uric acid in your joints. This also helps to reduce pain. The way that colchicine works for familial Mediterranean fever (FMF) is complicated. Colchicine can affect the way your white blood cells work.
Is colchicine bad for kidneys?
Colchicine is excreted renally and can accumulate to toxic levels in renal impairment. Colchicine is not contraindicated, but dose adjustment and close monitoring is suggested. Signs of toxicity include leukopenia, elevation of aspartate aminotransferase, and neuropathy.
Can you take colchicine everyday?
Adults—0.6 milligram (mg) 1 or 2 times a day. Your doctor may increase your dose as needed and tolerated. However, the dose is usually not more than 1.2 mg per day. Children—Use and dose must be determined by your doctor.
What are the three types of polyploidy?
Polyploids are organisms whose genomes consist of more than two complete sets of chromosomes. Stebbins distinguished three major types of polyploids: autopolyploids, allopolyploids and segmental allopolyploids (Stebbins, 1947).
What is an example of Amphidiploid?
For example, the F 1 hybrid resulting from a cross between a cabbage (Brassica sp.) and a radish (Raphanus sp.) is sterile. Yet such crosses may produce a few seeds that are capable of germinating into fertile F 2 plants.
How is colchicine used in the treatment of animals?
Colchicine is a tubulin polymerization inhibitor and is known to inhibit cytoplasmic transport and exocytosis (Thyberg and Moskalewski, 1985). Hence, treatment of animals with colchicine is commonly used to promote the accumulation of secretory proteins in the cytoplasm.
How is colchicine used in ghrelin immunoreaction?
Colchicine treatment enhances the ghrelin immunoreaction. Colchicine is a tubulin polymerization inhibitor and is known to inhibit cytoplasmic transport and exocytosis (Thyberg and Moskalewski, 1985). Hence, treatment of animals with colchicine is commonly used to promote the accumulation of secretory proteins in the cytoplasm.
What does colchicine do to the cytoplasm?
Colchicine is a tubulin polymerization inhibitor and is known to inhibit cytoplasmic transport and exocytosis (Thyberg and Moskalewski, 1985 ). Hence, treatment of animals with colchicine is commonly used to promote the accumulation of secretory proteins in the cytoplasm.
How is colchicine used in the treatment of FMF?
Colchicine is an antimitotic agent extracted from the autumn crocus (Colchicum autumnale). Colchicine is effective in the prophylaxis and treatment of acute attacks and development of renal amyloidosis in patients suffering from the Familial Mediterranean Fever (FMF). Colchicine crosses the placenta.