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What is TTP in clinical trials?

The length of time from the date of diagnosis or the start of treatment for a disease until the disease starts to get worse or spread to other parts of the body. In a clinical trial, measuring the TTP is one way to see how well a new treatment works. Also called time to progression.

How is TTP ash treated?

Treatment options for TTP refractory to PEX

  1. Corticosteroids. Corticosteroids are used in the acute management of acquired TTP, and should be started upfront together with PEX.
  2. Twice-daily PEX.
  3. Rituximab.
  4. Splenectomy.
  5. Cyclosporine.
  6. Cyclophosphamide and vincristine.
  7. Bortezomib.
  8. N-acetylcysteine.

What is the meaning of TTP?

Thrombotic thrombocytopenic purpura (TTP) is a blood disorder in which platelet clumps form in small blood vessels. This leads to a low platelet count (thrombocytopenia).

What is a TPP blood test?

Coombs Test This blood test is used to find out whether TTP is the cause of hemolytic anemia. For this test, a sample of blood is drawn from a vein, usually in your arm. In TTP, hemolytic anemia occurs because red blood cells are broken into pieces as they try to squeeze around blood clots.

What is congenital TTP?

Congenital thrombotic thrombocytopenic purpura (congenital TTP) is a blood disorder in which blood clots form in the small blood vessels throughout the body.

What does until disease progression mean?

(… pruh-GREH-shun) The length of time from the date of diagnosis or the start of treatment for a disease until the disease starts to get worse or spread to other parts of the body. In a clinical trial, measuring the time to progression is one way to see how well a new treatment works. Also called TTP.

Can TTP be cured?

Can TTP Be Cured? About 80% of patients will survive. The majority of patients will have only one episode of TTP; few will have relapses.

Who gets TTP?

It usually affects people between 20 to 50 years of age but people of any age may be affected. TTP is occasionally associated with pregnancy and collagen-vascular diseases (a group of diseases affecting connective tissue).

Can a histologic abnormality cause TTP and Hus?

Histologic abnormalities that are similar to TTP and HUS, most often seen in renal biopsies, can also occur in multiple other disorders and cause microangiopathic hemolytic anemia and thrombocytopenia that can mimic the clinical presentation of TTP and HUS. 5

Are there any new guidelines for the treatment of TTP?

In July 2020, the International Society on Thrombosis and Haemostasis (ISTH) issued its first-ever guidelines for the treatment of thrombotic thrombocytopenic purpura (TTP), helping clinicians make sense of some new, and not-so-new, treatment options for this rare and potentially fatal syndrome.

How is plasma exchange used to treat TTP?

Before the plasma exchange era, survival of patients with TTP was only 10%. 3 When plasma exchange was reported to increase survival to 78%, compared with 51% survival for patients treated with plasma infusion, 11 the diagnosis of TTP became an indication for plasma exchange treatment.

When does the first acute episode of TTP occur?

The first acute episode of TTP usually occurs during adulthood, with a predominant anti-ADAMTS13 autoimmune etiology. In rare cases, however, TTP begins as soon as childhood, with frequent inherited forms. TTP is ∼2-fold more frequent in women, and its outcome is characterized by a relapsing tendency.