What is the mechanism of action of rimantadine?
Amantadine and rimantadine are cyclic amines used in the treatment of influenza virus infection. The mechanism of action of these drugs involves inhibiting the uncoating of viral RNA in infected cells and thus effectively preventing viral replication.
What does flumadine treat?
Flumadine (rimantadine) is indicated for the prophylaxis and treatment of illness caused by various strains of influenza A virus in adults (17 years and older).
What is the use of rimantadine?
Rimantadine is used to prevent and treat infections caused by influenza A virus. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.
What is the mechanism of action of oseltamivir?
Mechanism of Action Oseltamivir inhibits the neuraminidase enzyme, which is expressed on the viral surface. The enzyme promotes release of virus from infected cells and facilitates viral movement within the respiratory tract.
Is rimantadine chiral?
Rimantadine was approved for medical use in 1993….Rimantadine.
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| Chirality | Racemic mixture |
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What type of drug is rimantadine?
Rimantadine, a cyclic amine, is a synthetic antiviral drug and a derivate of adamantane, like a similar drug amantadine. Rimantadine is inhibitory to the in vitro replication of influenza A virus isolates from each of the three antigenic subtypes (H1N1, H2H2 and H3N2) that have been isolated from man.
What are the contraindications of zanamivir?
Contraindications / Precautions
- General Information.
- Angioedema, milk protein hypersensitivity, serious rash.
- Viral infection.
- Cardiac disease, geriatric.
- Renal failure, renal impairment.
- Asthma, bronchitis, chronic obstructive pulmonary disease (COPD), emphysema, pulmonary disease.
- Administration via nebulizer.
- Vaccination.
Is zanamivir an antibiotic?
Is Relenza (zanamivir) an antibiotic? No, Relenza (zanamivir) is an antiviral and only works against the influenza virus. Antibiotics are used to fight bacterial infections.
What is the mechanism of action of Xofluza?
Mechanism of Action Baloxavir inhibits the endonuclease activity of the polymerase acidic (PA) protein, an influenza virus-specific enzyme in the viral RNA polymerase complex required for viral gene transcription, resulting in inhibition of influenza virus replication.
What is the medication classification of oseltamivir Tamiflu )?
Oseltamivir is in a class of medications called neuraminidase inhibitors. It works by stopping the spread of the flu virus in the body.
Who invented Idoxuridine?
It was synthesized by William Prusoff in the late 1950s. Initially developed as an anticancer drug, idoxuridine became the first antiviral agent in 1962.
Is lamivudine a nucleoside?
Lamivudine is a nucleoside analogue that is phosphorylated to lamivudine triphosphate by cellular kinases. Lamivudine inhibits the reverse transcriptase of both HBV and HIV, and is indicated for the treatment of HIV and chronic HBV infection.
How many mg of Flumadine is in a tablet?
Flumadine ® (rimantadine hydrochloride) is a synthetic antiviral drug available as a 100 mg film-coated tablet. Each film-coated tablet contains 100 mg of rimantadine hydrochloride plus hypromellose, magnesium stearate, microcrystalline cellulose, sodium starch glycolate, FD&C Yellow No. 6 Lake and FD&C Yellow No. 6.
How often should you take Flumadine for renal failure?
The recommended adult dose of Flumadine (rimantadine) is 100 mg twice a day for 7 days. In patients with severe hepatic dysfunction, severe renal impairment (CrCl 5 to 29 mL/min) or renal failure (CrCI ≤ 10 mL/min) and elderly nursing home patients, a dose reduction to 100 mg daily is recommended.
How is the pharmacokinetic profile of Flumadine determined?
PHARMACOKINETICS: Although the pharmacokinetic profile of Flumadine has been described, no pharmacodynamic data establishing a correlation between plasma concentration and its antiviral effect are available. Flumadine is absorbed after oral administration.
What is in the film coat of Flumadine?
The film coat contains hypromellose and polyethylene glycol. Rimantadine hydrochloride is a white to off-white crystalline powder which is freely soluble in water (50 mg/mL at 20°C).