What does nadir mean in cancer treatment?

When discussing chemotherapy side effects often you will hear the word nadir, mainly in reference to the blood counts, particularly white blood cell count and platelet count. Nadir basically means low point, however further explanation may clarify this term in connection with chemotherapy treatment.

What does nadir mean in medical terms?

The lowest point
Nadir: The lowest point. The nadir may refer, for example, to the lowest blood count after chemotherapy or the lowest concentration of a drug in the body.

What is nadir measurement?

Generally in medicine, nadir is used to indicate the progression to the lowest point of a clinical symptom (e.g. fever patterns) or a laboratory count. In oncology, the term nadir is used to represent the lowest level of a blood cell count while a patient is undergoing chemotherapy.

When does nadir occur?

It occurs at 7-14 days after undergoing a cycle due to cessation of normal production of blood cells (WBC, platelets, etc.), which increases the bleeding and/or infection risk.

What can increase white blood cells?

Poultry and Lean Meats. Foods high in protein, such as lean meats and poultry, are high in zinc — a mineral that increases the production of white blood cells and T-cells, which fight infection. Other great sources of zinc are oysters, nuts, fortified cereal, and beans.

How long does it take white blood cells to regenerate?

Your neutrophil count then starts to rise again. This is because your bone marrow restarts normal production of neutrophils. But it may take 3 to 4 weeks to reach a normal level again. When your neutrophil level returns to normal, you are ready for the next round of chemotherapy.

How quickly do white blood cells regenerate after chemo?

Fortunately, the effect of these drugs on the white blood cell count is usually both predictable and short-lived. The white cell count generally falls below the normal range about seven to ten days after a chemotherapy treatment and recovers within about a week after that.

What does nadir feel like?

This is called the nadir (pronounced nah-deer). You might feel very tired. Some people also feel depressed at this time. After the nadir, the level of white blood cells gradually goes up until it is almost back to normal.

How long does it take for white blood cells to increase after chemo?

Does sleep increase white blood cells?

Sleep restriction to four hours of sleep during three consecutive nights induced an increase in WBC counts, mainly neutrophils in young healthy subjects. The stress induced by the sleep restriction could be one mechanism involved.

What does Nadir stand for in cancer treatment?

More in Cancer. Nadir is a term that refers to the lowest point of anything. When used in reference to chemotherapy, it describes the point when blood cell counts are at their lowest after a chemotherapy treatment. It is commonly referred to as the “nadir period” or simply “nadir” among healthcare workers and patients.

What happens when your blood cell count is Nadir?

Each blood cell type reaches nadir at different times. Low counts have varying effects as well. Because permanent damage to bone marrow can occur if chemotherapy is given too often, this is taken into account when determining a chemotherapy schedule.

When to give chemotherapy after the nadir period?

Because permanent damage to bone marrow can occur if chemotherapy is given too often, this is taken into account when determining a chemotherapy schedule. The next dose of chemotherapy should be given only after a person’s blood counts have increased to safe levels after the nadir period.

What happens to platelets when they reach their nadir?

Platelets Platelets generally reach their nadir period at about the same time as white blood cells. Platelets serve an important function by helping blood to clot, which prevents bleeding. When the number of platelets in the body fall too low, the condition is called thrombocytopenia.