Is carbamazepine a teratogen?
Therefore, carbamazepine is considered a human teratogen as it leads to major and minor abnormalities in fetuses and babies such as developmental problems, abnormal IQ and growth retardation (32).
What are examples of teratogenic drugs?
Definition of Teratogenic drugs
- ACE (angiotensin converting enzyme) inhibitors such as:
- Acne medication isotretinoin (Accutane, Retin-A).
- Alcohol ingested chronically or in binges.
- Androgens (male hormones).
- Antibiotics tetracycline (Achromycin), and doxycycline (Vibramycin), and streptomycin.
Are tetracyclines teratogenic?
Tetracycline has been assigned to pregnancy category D by the FDA. Animal studies have revealed evidence of embryotoxicity and teratogenicity, including toxic effects on skeletal formation.
What are teratogenic medications?
Drugs that can cause birth defects are said to be ‘teratogenic drugs’. Medical science cannot always predict how exposure to a teratogenic drug will affect a developing fetus. It can be dangerous for a pregnant woman to stop taking prescription drugs if she has a medical condition or becomes ill.
What do teratogens include?
Teratogenic agents include infectious agents (rubella, cytomegalovirus, varicella, herpes simplex, toxoplasma, syphilis, etc.); physical agents (ionizing agents, hyperthermia); maternal health factors (diabetes, maternal PKU); environmental chemicals (organic mercury compounds, polychlorinated biphenyl or PCB.
Is lamotrigine a teratogen?
Anticonvulsants have been used to manage psychiatric conditions for over 50 years. It is recognised that some, particularly valproate, carbamazepine and lamotrigine, are human teratogens, while others including topiramate require further investigation.
What are 2 common teratogens?
Alcohol and smoking are two common teratogens. Exposure to either of them can lead to developmental anomalies, miscarriage, stillbirth, preterm labor, and a variety of other pregnancy complications.
Is stress a teratogen?
Maternal psychological stress has essentially been conceptualized as a teratogen, that is, an agent that can generate deleterious perinatal and/or developmental outcomes.
Can tetracyclines cause miscarriage?
Many classes of commonly prescribed antibiotics, including macrolides, quinolones, tetracyclines and sulfonamides may be associated with an increased risk of miscarriage during the first 20 weeks of pregnancy, a Canadian research study has concluded.
What are examples of tetracyclines?
Tetracyclines (tetracycline, doxycycline, minocycline, tigecycline) are a class of medication used to manage and treat various bacterial infections. Tetracyclines classify as protein synthesis inhibitor antibiotics and are considered to be broad-spectrum.
What are 3 examples of teratogens?
Common teratogens include some medications, recreational drugs, tobacco products, chemicals, alcohol, certain infections, and in some cases, uncontrolled health problems in the birthing parent. Alcohol is a well-known teratogen that can cause harmful effects on the fetus after exposure at any time during pregnancy.
Which is the best example of a teratogen?
Common teratogens include some medications, recreational drugs, tobacco products, chemicals, alcohol, certain infections, and in some cases, uncontrolled health problems in the birthing parent. Alcohol is a well-known teratogen that can cause harmful effects on the fetus after exposure at any time during pregnancy.
Are there any drugs that are Teratogenic agents?
Many prescribed drugs can act as teratogens including some anticonvulsant agents, lithium, androgens, retinoids, and misoprostol. Teratogenic agents may affect development of the embryo and fetus and upon exposure by a pregnant woman can cause birth defects, fetal loss or abnormal growth and development.
Why is trimethadione so important to pregnant women?
There is little justification for use of this particularly toxic drug in pregnant women. Nevertheless, trimethadione is important because it was the first maternal anticonvulsant treatment found to produce a unique pattern of abnormalities of growth and development in infants exposed prenatally (229,230).
Which is the most harmful teratogen in pregnancy?
Alcohol is a well-known teratogen that can cause harmful effects on the fetus after exposure at any time during pregnancy. Chickenpox is a teratogen that can potentially cause congenital varicella syndrome or neonatal varicella, depending on the timing of exposure.