In which position should the nurse place a patient following the administration of cytarabine liposomal?
DepoCyt is administered directly into the cerebrospinal fluid (CSF) via an intraventricular reservoir or by direct injection into the lumbar sac. DepoCyt should be injected slowly over a period of 1-5 minutes. Following drug administration by lumbar puncture, the patient should be instructed to lie flat for 1 hour.
How is cytarabine liposomal administered?
Liposomal cytarabine is given is by intraventricular or intrathecal infusion. This method is used when drugs need to reach the cerebrospinal fluid (CSF) the fluid that is surrounding the brain and spinal cord, the drug is infused directly into the spinal fluid.
Can you give cytarabine intrathecal?
Cytarabine may be given as an infusion into the vein (intravenous or IV). Another method it is given is by intrathecal infusion.
What does cytarabine do to cells?
Cytarabine is a type of chemotherapy drug. It kills cancer cells by stopping them from making and repairing DNA that they need to grow and multiply.
What is liposomal formulation?
Liposomes are round bubbles consisting of an aqueous core encapsulated by natural or synthetic phospholipids. This structure turns liposomes into ideal drug carriers, since hydrophilic drugs tend to be entrapped in the core; while hydrophobic ones will be entrapped within the lipid bilayers.
How does an Ommaya reservoir work?
An Ommaya Reservoir is a small, plastic device that is implanted in your brain. It allows your doctor to deliver medicine directly to the fluid around your brain and spinal cord. It also allows your doctor to take samples of the fluid around your spinal cord to test it.
What are the side effects of cytarabine?
Cytarabine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- stomach pain.
- loss of appetite.
- sores in the mouth and throat.
- hair loss.
- muscle or joint pain.
Does cytarabine cause hair loss?
It is also FDA approved for use with other drugs to treat acute myeloid leukemia, acute lymphoblastic leukemia and chronic myeloid leukemia. This medicine may cause a temporary loss of hair in some people. After treatment with cytarabine has ended, normal hair growth should return.
What is the benefit of liposomal preparation?
The application of liposomes to assist drug delivery has already had a major impact on many biomedical areas. They have been shown to be beneficial for stabilizing therapeutic compounds, overcoming obstacles to cellular and tissue uptake, and improving biodistribution of compounds to target sites in vivo.
What is the meaning of liposomal?
(LY-poh-SOH-mul) A drug preparation that contains the active drug inside very tiny, fat-like particles. This form is easier for the body to absorb and allows more drug to get to the target area of the body, such as a tumor.
Can an Ommaya reservoir be removed?
Ommaya reservoirs usually aren’t removed unless they cause problems, such as an infection. Though at some point in the future you may no longer need your Ommaya reservoir, the process to remove it carries the same risks as the process to implant it.