How do you administer Activase?
The recommended treatment dose of Activase is 0.9 mg/kg (not to exceed 90 mg total treatment dose) infused over 60 minutes. 6
- 10% of the total treatment dose should be administered as an initial bolus over 1 minute.
- The remaining treatment dose should be infused intravenously over 60 minutes.
What are your responsibilities during the administration of Activase tPA?
When Activase is administered, the first 24 hours are critical. Observe and frequently monitor patients for neurologic changes, as well as any signs and symptoms of intracranial hemorrhage and adverse drug reactions, during patient recovery.
How do you administer tissue plasminogen activator?
Adults patients: Initially administer 10 units IV bolus (over 2 minutes) with the second dose given 30 minutes after first (for a total cumulative dose of 20 units). An IV line is used to administer the bolus injection, and no other medication should be simultaneously injected or infused through this IV line.
Can you mix alteplase with normal saline?
Conclusions: Alteplase diluted in normal saline solution at a concentration of 0.01 mg/mL is biochemically stable and active at ambient temperature for as long as 24 hours as assessed by in vitro clot lysis assays.
How quickly does tPA work?
When administered quickly after stroke onset (within three hours, as approved by the FDA), tPA helps to restore blood flow to brain regions affected by a stroke, thereby limiting the risk of damage and functional impairment.
What are the major side effects of tPA?
The most common and serious side effect of alteplase is bleeding. Minor bleeding is more common, but significant bleeding such as into the brain (intracranial hemorrhage) or fatal bleeding also occurs. Other important side effects include: Nausea.
Why can you only give tPA within 3 hours?
The timing of treatment is important, because giving a strong blood thinner like tPA during a stroke can cause bleeding inside the brain. The longer a patient waits to get treatment, the more likely it is that the risks of treatment will outweigh the benefits.
How long does it take to administer tPA?
Alteplase (IV r-tPA) within 4.5 hours of stroke onset remains the standard of care for most ischemic stroke patients.
How fast is tPA administered?
What happens if tPA is given after 3 hours?
“From analyzing all the available data, tPA [tissue plasminogen activator] after 3 hours for stroke patients may not be of any benefit but has a definite risk of fatal bleeding,” Dr Alper told Medscape Medical News.
What happens if extravasation of activase occurs?
2. Program an infusion pump to flush the IV tubing following administration of treatment dose. Activase is for intravenous administration only. Extravasation of Activase infusion can cause ecchymosis or inflammation. If extravasation occurs, terminate the infusion at that IV site and apply local therapy.
How long does it take to take a bolus of activase?
Monitor patients during and post Activase ® administration. The recommended treatment dose of Activase is 0.9 mg/kg (not to exceed 90 mg total treatment dose) infused over 60 minutes. . 10% of the total treatment dose should be administered as an initial bolus over 1 minute.
How to administer activase in a prime infusion set?
Peel the clear plastic hanger from the vial label. Hang the Activase vial from the resulting loop. Administer using either a polyvinyl chloride bag or a glass vial and infusion set. Prime infusion set tubing with Activase solution and administer initial IV bolus over 1 minute. Administer remainder.
How many milligrams of activase should I take?
The recommended treatment dose of Activase is 0.9 mg/kg (not to exceed 90 mg total treatment dose) infused over 60 minutes. 10% of the total treatment dose should be administered as an initial bolus over 1 minute The remaining treatment dose should be infused intravenously over 60 minutes