What is the pathogenesis of Ebola?

Pathogenesis. Ebola virus enters the patient through mucous membranes, breaks in the skin, or parenterally and infects many cell types, including monocytes, macrophages, dendritic cells, endothelial cells, fibroblasts, hepatocytes, adrenal cortical cells, and epithelial cells.

What is Ebola virus Slideshare?

Ebola Virus Disease (EVD) • Ebola virus disease is a severe, fatal, zoonotic filovirus infection • The current outbreak in west Africa, (first case notified in 1976) • Fatality rates are between 80% and 100% • This filovirus is classified as a biological class 4 pathogen • The most severely affected countries are …

What is the mechanism of Ebola?

Ebola virus takes advantage of a non-specific engulfing process called macropinocytosis, which allows the virus to be “eaten” by a wave-like motion of the cell membrane (Figure 1) [2]. Once inside the cell, the virus hijacks the cell’s own machinery to create more copies of itself.

How is Ebola spread from human to human?

Ebola can spread when people come into contact with infected blood or body fluids. Ebola poses little risk to travelers or the general public who have not cared for or been in close contact (within 3 feet or 1 meter) with someone sick with Ebola.

What classification is Ebola?


Ebolavirus, genus of viruses in the family Filoviridae, certain members of which are particularly fatal in humans and nonhuman primates. In humans, ebolaviruses are responsible for Ebola virus disease (EVD), an illness characterized primarily by fever, rash, vomiting, diarrhea, and hemorrhaging.

What morphology is Ebola?

Virology. Ebola virus and the closely related Marburg virus (MARV) are members of the Filoviridae family, named for the filamentous morphology of virions that appear by electron microscopy to be a consistent diameter of approximately 80 nm, but nonuniform in length.

What can cause Ebola?

What causes Ebola virus disease?

  • Blood of a person infected with the virus.
  • Body fluids, such as breast milk, stool, saliva, semen, sweat, urine, or vomit, of a person infected with the virus.
  • Objects, such as needles or syringes, that are contaminated with the virus.

What is the scientific name of Ebola?

Ebola virus (species Zaire ebolavirus)

What are the symptoms of Ebola in humans?

Symptoms include Vomiting Stomach pain Muscle pain Unexplained bleedingor bruising Symptoms include Only 3 in 10 of the people who have gotten Ebola during this outbreak have gotten better.

How does Ebola spread from person to person?

People can spread the virus to other people when they are very sick. This is the main way that people are now getting Ebola in West Africa. What have you heard about the Ebola outbreak?

What is the lifecycle of the Ebola virus?

The lifecycle of the Ebola virus in host cells NCBI Skip to main content Skip to navigation Resources How To About NCBI Accesskeys My NCBISign in to NCBISign Out PMC US National Library of Medicine National Institutes of Health

Where does the Ebola virus live in Africa?

EBOLA? Ebola is a virus that lives in bats and some other animals who live in Africa. What is EBOLA? People can get Ebola in West Africa by preparing these sick animals for food. What is EBOLA? People can spread the virus to other people when they are very sick. This is the main way that people are now getting Ebola in West Africa.