By 4 min read

What is the class of dextromethorphan?

Dextromethorphan is in a class of medications called antitussives.

What are BCS Class 2 drugs?

BCS Class IIa drugs, typically carboxylic acids with a pKa in the range of 4 to 5, are insoluble at typical, fasted, gastric pHs but soluble at intestinal pHs and, hence, are classified as BCS Class II or IV depending on intestinal jejunal permeability at pH = 6.5 or fraction dose absorbed determination in humans.

What is BCS classification example?

The Biopharmaceutical Classification System was first developed by in 1995, by Amidon et al & his colleagues. Definition: “The Biopharmaceutical Classification System is a scientific framework for classifying a drug substance based on its aqueous solubility & intestinal permeability & dissolution rate”.

What BCS class is acyclovir?

According to the Biopharmaceutics Classification System (BCS) and considering tablet strengths up to 400 mg, aciclovir would be BCS Class III.

What are the contraindications of dextromethorphan?

Contraindications / Precautions

  • Asthma, emphysema, tobacco smoking. Dextromethorphan is contraindicated in the treatment of chronic cough, especially when associated with excessive bronchial secretion.
  • Hepatic disease.
  • Children, infants.
  • Pregnancy.
  • Breast-feeding.
  • Driving or operating machinery.
  • MAOI therapy.
  • Geriatric.

How is BCS classification determined?

The drugs are classified in BCS on the basis of solubility, permeability, and dissolution. Solubility class boundaries are based on the highest dose strength of an immediate release product.

What are BCS 3 drugs?

BCS Class III drug substances are considered to be more susceptible to the effects of excipients. These drugs are not considered highly permeable and may have site-specific absorption, so there are a greater number of mechanisms through which excipients can affect their absorption than for BCS Class I drugs.

What kind of BCS is acetaminophen Class III?

According to the current BCS criteria, acetaminophen is BCS Class III compound. Differences in composition seldom, if ever, have an effect on the extent of absorption. However, some studies show differences in rate of absorption between brands and formulations.

Which is more stable trimethoprim I or II?

Stability studies by pH determinations, HPLC assays, & visual inspections for precipitate showed that I was stable in all admixtures during the study period, whereas the stability of II was dependent on concn & vehicle. Trimethoprim was more stable in III injection & stability decreased with increasing concns.

How many PubChem synonyms are there for trimethoprim?

Trimethoprim PubChem CID 5578 Synonyms trimethoprim 738-70-5 Proloprim Trimpex Molecular Weight 290.32 Date s Modify 2021-06-12 Create 2005-03-25

How much does trimethoprim weigh in PubChem CID 5578?

Trimethoprim PubChem CID 5578 Synonyms trimethoprim 738-70-5 Proloprim Trimpex Molecular Weight 290.32 Date s Modify 2021-06-26 Create 2005-03-25