What is PVP K90?
Polyvinylpyrrolidone (PVP),also known as K90 is a water soluble polymer with good bio-stability. It is chemically stable, has low toxicity and is biocompatible. Hence, it is useful in a variety of applications such as cosmetics, tissue engineering, and biomedical engineering.
Is povidone soluble in water?
What is K value of PVP?
|Grade||K-Value Range||Molecular Weight (GPC/MALLS)|
Why is PVP a good binder?
As a binder, PVP is used in the concentration range of 0.5%–5% w/w. Wet granulation with povidone K25/30/90 generally gives harder granules with better flow properties than with other binders with lower friability and higher binding strength. Moreover, povidone also promotes the dissolution of APIs.
Is PVP k90 safe?
Review, 1101 17th Street, NW, Suite 310, Washington, DC 20036, USA. available data, it was concluded that PVP is safe as used in cosmetics. a molecular weight (MW) of 111.1; the molecular weight of the poly- mer can range from 10,000 to 700,000 (IARC 1979).
What is povidone used for?
POVIDONE IODINE (poe-vee-don ahy-uh-din) is used on the skin to decrease risk of infection. This medicine is also used as a surgical hand scrub and to wash the skin and surface of the eye before surgery to help prevent infections.
What is the difference between povidone and crospovidone?
Polyvinylpyrrolidone (PVP), also commonly called polyvidone or povidone, is a water-soluble polymer made from the monomer N-vinylpyrrolidone. As a food additive, PVP is a stabilizer and has E number E1201. PVPP (crospovidone) is E1202. It is also used in the wine industry as a fining agent for white wine or some beers.
How do you calculate the k value of povidone?
the Viscosity Determination, and calculate the K-value by the following formula. Povidone having a nominal K-value exceeding 15 is not less than 90.0 % and not more 191 Page 6 001-1307PDG.pdf 6 than 108.0 % of the nominal K-value. K = 1.5logν rel. -1 0.15+0.003c + 300clogν rel.
How do you make a 1 PVP solution?
In brief, the PVP solution was prepared by dissolving 0.5 g of PVP in 10 mL of deionized water at room temperature for 2 h under agitation. The PVP/CNC ratio was controlled by stoichiometric addition of a CNC suspension to a fixed quantity of the PVP solution followed by vigorous stirring for 1 h.
Is PVP a binder?
PVP or povidone is a hygroscopic, amorphous, synthetic polymer consisting of linear 1-vinyl-2-pyrrolidinone groups. As a binder, PVP is used in the concentration range of 0.5%–5% w/w. Different degrees of polymerization of PVP resulted in polymers of various molecular weights.
Is PVP bad for hair?
PVP/VA copolymer is the ingredient found in most hair care products that provides the “hold factor.” (Think: hairsprays.) It is another toxic chemical derived from petroleum that’s known to cause irritation to the scalp, as well as respiratory issues in some people.
Is povidone bad?
Large ingestions of povidone are expected to cause only minimal symptoms such as diarrhea. If povidone gets into the eyes or onto the skin, it might cause irritation and pain. There have been reports of severe allergic reactions occurring in sensitive people, but this reaction is rare.
What does the K in povidone K90 mean?
The k number refers to the mean molecular weight of the povidone. Povidones with higher K-values (i.e., k90) are not usually given by injection due to their high molecular weights.
What is the k value of povidone in nitrogen?
Povidone is a chain polymer of 1-vinyl-2-pyrrolidone. It contains NLT 11.5% and NMT 12.8% of nitrogen (N: 14.01), calculated on the anhydrous basis. It has the nominal K-value of NLT 10 and NMT 120.
Why are povidones not given as an injection?
Povidones with higher K-values (i.e., k90) are not usually given by injection due to their high molecular weights. The higher molecular weights prevent excretion by the kidneys and lead to accumulation in the body.
How are plasdone povidones used in the pharmaceutical industry?
Plasdone povidones are commonly used as binders for the development of tablet formulations, whether manufactured by wet granulation, dry granulation or direct compression. Plasdone K polymers are used in solid-dispersion formulations to enhance the solubility of active pharmaceutical ingredients and increase bioavailability.