What class is clofarabine?
Clofarabine is in a class of medications called purine nucleoside antimetabolites. It works by killing existing cancer cells and limiting the development of new cancer cells.
Who makes clofarabine?
In January 2016, Genzyme Corporation was rebranded as Sanofi Genzyme (Sanofi 20-F, March 2016). Dr. Reddy’s Laboratories, in November 2017, launched a generic version of clofarabine injection, in the US .
How long does cytarabine stay in your body?
Nadir: White blood cells: 7-10 days, platelets: 12-15 days.
Can you kiss a chemo patient?
Kissing is a wonderful way to maintain closeness with those you love and is usually okay. However, during chemotherapy and for a short time afterward, avoid open-mouth kissing where saliva is exchanged because your saliva may contain chemotherapy drugs.
Does Ara C cause hair loss?
This medicine may cause a temporary loss of hair in some people. After treatment with cytarabine has ended, normal hair growth should return.
How old do you have to be to take clofarabine?
FDA label information for this drug is available at DailyMed. Clofarabine is approved to treat: Acute lymphoblastic leukemia that has recurred (come back) or is refractory (does not respond to treatment) in children and young adults aged 1 to 21 years who have already had at least two other types of treatment.
What kind of drug is clofarabine used for?
Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed in the U. S. and Canada as Clolar. In Europe and Australia/New Zealand the product is marketed under the name Evoltra.
Are there any known overdoses of clofarabine in humans?
There were no known overdoses of clofarabine. The highest daily dose administered to a human to date (on a mg/m 2 basis) has been 70 mg/m 2 /day × 5 days (2 pediatric ALL patients). The toxicities included in these 2 patients included grade 4 hyperbilirubinemia, grade 2 and 3 vomiting, and grade 3 maculopapular rash.
How does clofarabine inhibit DNA repair and synthesis?
Clofarabine is phosphorylated intracellularly to the cytotoxic active 5′-triphosphate metabolite, which inhibits the enzymatic activities of ribonucleotide reductase and DNA polymerase, resulting in inhibition of DNA repair and synthesis of DNA and RNA.