What are DRESS symptoms?
Patients with DRESS can have a broad range of symptoms, which can include fever, rash, facial swelling, enlarged lymph nodes and kidney or liver injury. Most patients with DRESS will have an abnormal level of blood cells found in their blood tests, which are called eosinophils.
What is dapsone hypersensitivity syndrome?
Dapsone syndrome is an uncommon hypersensitivity reaction to diamino diphenyl sulfone. This syndrome is characterised by high fever, maculopapular rashes, hepatitis, lymphadenopathy and lymphocytosis. It generally appears within first 6 weeks of treatment [1].
Can dapsone cause Steven Johnson Syndrome?
Table 1 lists the multiple adverse effects of Dapsone, including the dapsone hypersensitivity syndrome (DHS) and DRESS syndrome….Table 1.
| System | Manifestations | Mechanisms |
|---|---|---|
| Methemoglobinemia | Predictable | |
| Neurological | Peripheral neuropathy | Predictable |
| Dermatological | Stevens-Johnson Syndrome | Idiosyncratic |
How do you treat DRESS syndrome?
Patients with DRESS syndrome should be managed in an intensive care or burn unit for appropriate care and infection control. In addition, appropriate specialists should be consulted based on the affected organ systems. Most patients recover completely after drug withdrawal and appropriate therapy.
What meds cause DRESS syndrome?
Medicines most commonly associated with DRESS syndrome are anticonvulsants, antibiotics (particularly beta-lactams), and allopurinol. Other medications that are known to be associated with DRESS include non-steroidal anti-inflammatory drugs, captopril, mood stabilisers, and antiretrovirals.
What does DRESS rash look like?
The rash has been described as morbilliform or “measles like”, and begins 2-6 weeks after initiating the culprit medication (Figure 1). It is often maculopapular and involves the face, trunk, and upper extremities before spreading downward to involve >50% of the body surface area (BSA).
What are the long term side effects of taking dapsone?
Rarely, prolonged use of dapsone over months or years at a high dose can lead to impaired function of nerves in the limbs, causing weakness of muscles in the hands and feet.
What happens when you stop taking dapsone?
If you stop taking this medicine too soon, your symptoms may return. This medicine works best when there is a constant amount in the blood. To help keep the amount constant, do not miss any doses. Also, it is best to take each dose at the same time every day.
What can trigger Steven Johnson Syndrome?
Stevens-Johnson syndrome is usually caused by an unpredictable adverse reaction to certain medications. It can also sometimes be caused by an infection. The syndrome often begins with flu-like symptoms, followed by a red or purple rash that spreads and forms blisters. The affected skin eventually dies and peels off.
Does dapsone make you tired?
Seek immediate medical attention if you develop signs of an infection (e.g., fever, chills, persistent sore throat), easy bruising/bleeding, unusual tiredness, pale skin, yellowing eyes/skin, dark urine, stomach/abdominal pain. Dapsone can commonly cause a rash that is usually not serious.
What drugs can cause DRESS syndrome?
Is DRESS syndrome the same as Red Man Syndrome?
Introduction. DRESS (drug reaction and eosinophilia with systemic symptoms) syndrome is a severe drug-induced reaction most typically characterized by fevers, lymphadenopathy, transaminitis, kidney injury, and/or rash. We present a case of DRESS syndrome after vancomycin administration masquerading as Red Man syndrome.