Can lorazepam injection be given subcutaneously?

Treatment in all patients should be withdrawn gradually to minimise possible withdrawal symptoms (see section 4.4). Ativan Injection can be given intravenously or intramuscularly. However, the intravenous route is to be preferred. Care should be taken to avoid injection into small veins and intra-arterial injection.

How do you administer lorazepam IV?

Lorazepam 0.5 mg/mL dilution: Add 1 mL of lorazepam (2 mg/mL) to 3 mL of 5% Dextrose Injection or NS (benzyl alcohol content = 5 mg/mL if using a lorazepam product containing 2% benzyl alcohol). After dilution, inject directly into a vein or into the tubing of a freely-flowing compatible IV infusion.

Where do you inject lorazepam?

A nurse or other trained health professional will give you this medicine. This medicine is given through a needle placed in one of your veins or given as a shot into one of your muscles.

How do you dissolve lorazepam?

Dissolve lorazepam place 0. Dissolve lorazepam place 0.5 to 1 mg tablet in 1-2 cc water. Once dissolved, “dribble” under tongue with small syringe q 1 hour.

Does lorazepam need to be diluted prior to administration?

Immediately prior to intravenous use, ATIVAN Injection must be diluted with an equal volume of compatible solution. Contents should be mixed thoroughly by gently inverting the container repeatedly until a homogenous solution results. Do not shake vigorously, as this will result in air entrapment.

What is the recommended dose of lorazepam for injection?

Intramuscular Injection. For the designated indications as a premedicant, the usual recommended dose of lorazepam for intramuscular injection is 0.05 mg/kg up to a maximum of 4 mg. As with all premedicant drugs, the dose should be individualized (see also CLINICAL PHARMACOLOGY, WARNINGS, PRECAUTIONS, and ADVERSE REACTIONS).

Are there any side effects from lorazepam injection?

Concurrent administration of any of the following drugs with lorazepam had no effect on the pharmacokinetics of lorazepam: metoprolol, cimetidine, ranitidine, disulfiram, propranolol, metronidazole, and propoxyphene. No change in ATIVAN dosage is necessary when concomitantly given with any of these drugs.

How long does it take for lorazepam to be absorbed?

Following intramuscular administration, lorazepam is completely and rapidly absorbed reaching peak concentrations within 3 hours. A 4-mg dose provides a Cmaxof approximately 48 ng/mL. Following administration of 1.5 to 5.0 mg of lorazepam IM, the amount of lorazepam delivered to the circulation is proportional to the dose administered.

When to use im Ativan instead of lorazepam?

An intravenous infusion should be started, vital signs should be monitored, an unobstructed airway should be maintained, and artificial ventilation equipment should be available. IM ATIVAN is not preferred in the treatment of status epilepticus because therapeutic lorazepam levels may not be reached as quickly as with IV administration.